Increased Neurotoxicity Following Concurrent Exposure to Pyridostigmine Bromide, DEET, and Chlorpyrifos
نویسندگان
چکیده
منابع مشابه
Research on Multiple Chemical Sensitivity ( MCS )
This document lists citations for peer-reviewed journal articles that support a physiological basis for MCS. Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alt...
متن کاملSensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats.
A myriad of neurological symptoms including muscle and joint pain, ataxia, chronic fatigue, headache, and difficulty in concentration have been reported by Persian Gulf War (PGW) veterans. A large number of these veterans were prophylactically treated with pyridostigmine bromide (PB) and possibly exposed to sarin. In the present study we investigated the effects of PB and sarin, alone and in co...
متن کاملDevelopmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?
The developmental neurotoxicity of chlorpyrifos (CPF) involves mechanisms over and above cholinesterase inhibition. In the present study, we evaluated the effects of gestational CPF exposure on the adenylyl cyclase (AC) signaling cascade, which regulates the production of cyclic AMP, a major controller of cell replication and differentiation. In addition to basal AC activity, we assessed the AC...
متن کاملIn vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide.
Oxidative metabolism of the insect repellent N,N-diethyl-m-toluamide (DEET) by pooled human liver microsomes (HLM), rat liver microsomes (RLM), and mouse liver microsomes (MLM) was investigated. DEET is metabolized by cytochromes P450 (P450s) leading to the production of a ring methyl oxidation product, N,N-diethyl-m-hydroxymethylbenzamide (BALC), and an N-deethylated product, N-ethyl-m-toluami...
متن کاملEffect of pyridostigmine bromide on serum bromide concentration and the anion gap.
B romide (Br) causes positive interference with all clinical laboratory methods for the detenmination of serum Cl (1 .2). Interference with Cl measurement is much greater with ion-selective electrode (ISE) technology (1 .3) than with coubometry (1 -4). We recently described a patient ingesting therapeutic amounts of pynidostigmine Br (MestInon1 , containing 1 8.4 mg of Br [30.6%j per 60-mg tabl...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1996
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/34.2.201